生物医学工程
-
胡祥龙
特任研究员、博士生导师
胡祥龙博士、中国科学技术大学生物医学工程学院、化学与材料科学学院 特任研究员、博士生导师、创新生物医药与材料课题组负责人。2014年获得中国科学技术大学博士学位 (导师：刘世勇教授)；2017-2019年在香港科技大学从事香江学者计划博士后研究 (导师：唐本忠院士)；2022年加入中国科学技术大学高分子科学与工程系。
迄今，在J. Am. Chem. Soc. (4篇), Angew. Chem. Int. Ed. (3篇) 等期刊以第一/通讯作者发表论文40余篇，曾分别被Nature出版社周刊SciBX 专栏评述、入选JACS亮点论文专栏并发文报道、入选德国应用化学VIP论文并被Wiley和Newswise分别发文报道、入选Research期刊2020最佳论文、受邀为Chemistry-A European Journal撰写Concept论文等，SCI论文总引用5500余次，H指数38；担任Nat. Chem., Nat. Commun., Adv. Mater., ACS Nano, Adv. Funct. Mater.等期刊审稿人、担任中国化学会高级会员、中国生物医学工程学会青年委员、广东省精准医学应用学会分子影像分会常务委员、广东省药物手性专委会委员、Asian J. Pharm. Sci.青年编委等；主持多项国家自然科学基金，作为骨干参加一项国家重点研发计划项目；作为主要发明人获授权10余项中国发明专利。
E-mail: huxlong@ustc.edu.cn
Wechat link:
主要研究方向
i) 功能高分子与光学材料研究，包括生物医用高分子、聚集诱导发光材料等；
ii) 创新生物医药与制剂开发，如聚前药技术、功能蛋白、脂质体等；
iii) 生物医学诊疗方案开发，涉及肿瘤、感染与炎症、镇痛、抗衰修复等；
基于临床与应用需求，重视源头创新，设计构筑新分子与新材料，探索生物医学与材料科学中的关键问题；曾发展了一种“聚前药Polyprodrug”策略，用于高效可控药物递送与疾病诊疗，引发基础研究兴趣与产业关注。
获奖及荣誉情况
1. 2020年获评Research最佳论文奖
2. 2019年 广州市珠江科技新星
3. 2017年 香江学者奖
4. 2016年 广东省杰出青年基金获得者
5. 2016年 广东省特支科技创新青年拔尖人才(结题获评优秀)
6. 2015年 中国科学院优秀博士学位论文
代表论著
1. C. Z. Song, M. L. Chen, J. J. Tan, J. Xu, Y. B. Zhang, G. Y. Zhang, X. L. Hu*, S. Y. Liu* ““Self-Amplified Cascade Degradation and Oxidative Stress Via Rational pH Regulation of Oxidation-Responsive Poly(ferrocene) Aggregates” Journal of the American Chemical Society 2023, 145, 17755-17766.
2. W. H. Wang, Y. T. Zhang, Z. S. Wang, X. P. Liu, S. Y. Lu, X. L. Hu* "A Native Drug-Free Macromolecular Therapeutic to Trigger Mutual Reinforcing of Endoplasmic Reticulum Stress and Mitochondrial Dysfunction for Cancer Treatment" ACS Nano 2023, 17, 11023-11038.
3. J. Xu, J. J. Tan, C. Z. Song, G. Y. Zhang, X. L. Hu*, S. Y. Liu* "Self‐Immolative Amphiphilic Poly (ferrocenes) for Synergistic Amplification of Oxidative Stress in Tumor Therapy" Angewandte Chemie-International Edition 2023, 62, e202303829. (VIP paper, highlighted by Wiley Press Release and Newswise, respectively)
4. Q. Q. Shi, Z. Y. Deng, M. X. Hou, X. L. Hu*, S. Y. Liu* "Engineering precise sequence-defined polymers for advanced functions" Progress in Polymer Science 2023, 141, 101677.
5. Z. X. Wang, M. X. Zhan*, X. L. Hu* “Pulsed Laser Excited Photoacoustic Effect for Disease Diagnosis and Therapy” Chemistry-A European Journal 2022, 28, e202200042 (Invited Concept).
6. Z. X. Wang, M. X. Zhan, W. J. Li, C. Y. Chu, D. Xing*, S. Y. Lu, X. L. Hu* “Photoacoustic Cavitation-Ignited Reactive Oxygen Species to Amplify Peroxynitrite Burst by Photosensitization-free Polymeric Nanocapsules” Angewandte Chemie-International Edition 2021, 60, 4720-4731. (ESI Highly Cited Papers)
7. C. Y. Wang, Wei Zhao, B. Cao, Z. X. Wang, Q. Zhou, S. Y. Lu, L. Lu, M. Zhan*, X. L. Hu* “Biofilm-Responsive Polymeric Nanoparticles with Self-adaptive Deep Penetration for In Vivo Photothermal Treatment of Implant Infection” Chemistry of Materials 2020, 32, 7725-7738.
8. C. Z. Yao, Y. M. Li, Z. X. Wang, C. Z. Song, X. L. Hu*, S. Y. Liu* “Cytosolic NQO1 Enzyme-Activated Near-Infrared Fluorescence Imaging and Photodynamic Therapy with Polymeric Vesicles” ACS Nano 2020, 14, 1919-1935.
9. X. L. Liu, M. G. Li, T. Han, B. Cao, Z. J. Qiu, Y. Y. Li, Q. Y. Li, Y. B. Hu, Z. Y. Liu, Jacky W. Y. Lam*, X. L. Hu*, B. Z. Tang* “In-situ Generation of Azonia-containing Polyelectrolytes for Luminescent Photopatterning and Superbug Killing” Journal of the American Chemical Society 2019, 14, 11259-11268.
10. D. Wang*, M. S. Lee, W. H. Xu, G. G. Shan, X. Y. Zheng*, Ryan T. K. Kwok, Jacky W. Y. Lam, X. L. Hu*, B. Z. Tang* “Boosting Non-Radiative Decay to Do Useful Work: Development of Multi-Modality Theranostic System from AIEgen” Angewandte Chemie-International Edition 2019, 58, 5628-5632. (ESI Highly Cited Papers)
11. X. L. Hu#, X. Q. Zhao#, B. Z. He, Z. Zhao, Z. Zheng, P. F. Zhang, X. J. Shi, Ryan T. K. Kwok, Jacky W. Y. Lam, A. J. Qin, B. Z. Tang* “A Simple Approach to Bioconjugation at Diverse Levels: Metal-Free Click Reactions of Activated Alkynes with Native Groups of Biotargets without Prefunctionalization” Research 2018, 2018, 3152870. (Best Paper Award 2020)
12. X. L. Hu, G. H. Liu, Y. Li, X. R. Wang, S. Y. Liu* "Cell-Penetrating Hyperbranched Polyprodrug Amphiphiles for Synergistic Reductive Milieu-Triggered Drug Release and Enhanced Magnetic Resonance Signals", Journal of the American Chemical Society 2015, 137, 362-368. (Highlighted by JACS Spotlights, doi: 10.1021/ja512889n; “ESI Highly Cited Papers”)
13. X. L. Hu, J. M. Hu*, J. Tian, Z. S. Ge, G. Y. Zhang, K. F. Luo, S. Y. Liu* “Polyprodrug Amphiphiles: Hierarchical Assemblies for Shape-Regulated Cellular Internalization, Trafficking and Drug Delivery” Journal of the American Chemical Society 2013, 135, 17617-17629. (Highlighted by SciBX, doi: 10.1038/scibx.2013.1366; rated as “ESI Hot Papers”, “ESI Highly Cited Papers”)
